Used this quote recently (at the MoQ Conference), and admitted I couldn’t recall it’s source.
No, not Shakespeare dummy – it’s a deliberate play on the Tempest quote.
Best documented web source is Thomas Disch, who used this as the title of his book about how Sci-Fi “conquered” the world.
I first saw the phrase as a signature line on some mail discussion forum, and it is frequently referred to as a quote by “a” physicist, alluding to the fact that quantum physical reality is 99.9999% vacuum. The only attribution I can find is David Moser (?)
[BTW – “Science Fiction” – I like the ambiguity, the fiction that is science.]