Upgraded to WordPress 2.0.5 yesterday and installed Akismet comment-spam-killer today. And it all seems to be working. Long overdue, I was running at 70 odd per day, and it was getting very tiresome to filter by hand before allowing comments through.
One observation on the arrangement, I use WordPress s/w from WordPress.ORG hosted at Dreamhost.COM, but Akismet requires registration with services from WordPress.COM ? Anyway, as I say it seems to be working.